![]() MreB is largely conserved, and assembles in a nucleotide-dependent manner into short filaments associated with the inner side of the cytoplasmic membrane 3– 8. ![]() Proteins that are involved in PG biosynthesis associate in dynamic multi-membered complexes that regulate cell division (the “divisome”) and cell wall elongation (the “elongasome”, or Rod system), and their inhibition or deregulation can lead to defects in cell shape, impaired growth, and often cell wall lysis and death 1, 2.Ī key protein that regulates the positioning of the elongasome during the steps viewing incorporation of new PG along the lateral cell wall is the actin homolog MreB. The PG is an essential heteropolymer that surrounds most bacterial cells, offering protection from osmotic lysis, and its biosynthetic machinery has been the target of successful antibiotics for decades. Bacterial survival and morphogenesis are highly dependent on the peptidoglycan (PG), a key component of the cell wall.
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